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050, CI 1.010-1.093, = 0.015 and OR 1.063, CI 1.026-1.101, = 0.001, respectively) and higher BMI was associated with major polypharmacy (OR 1.186, CI 1.18-1.29, = 0.001). The rates of discontinuation of first DMT were similar among the three groups (50.7% for no-Poly RRMS, 50.8% for minor-Poly RRMS, and 53.3% for major-Poly RRMS, = 0.264). At log-Rank test, there were no differences among the three groups ( = 0.834). Polypharmacy was more common in older RRMS patients with high BMI. Polypharmacy was more common in older RRMS patient