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© 2020 The Authors. Alzheimer's Dementia published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association.The 250-year anniversary of Cook's landfall at Botany Bay on 28 April 1770, approximately half way through a global circumnavigation, was an extraordinary maritime undertaking. An enterprise of astronomy, cartography, cultural-botanical documentation and revelation achieved without a death from infectious disease and only 10 mild cases of scurvy in a ship's company of 95 men. The subsequent homeward journey was far l