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Conventional β-lactam antibiotics are resisted by bacteria at an increasing rate, prompting studies into the development of alternate antibiotic agents. In this personal account, we summarize recent progress in the design and engineering of graphene oxide quantum dot-based nanomaterials as potent antimicrobial agents. Specifically, we examine the impacts of chemical reduction on the antimicrobial activity of graphene oxide quantum dots, and enhancement of the bactericidal performance by the formation of nanocomposites with metal oxide na