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To clarify the effects of unfused cranial bones on magnetoencephalography (MEG) signals during early development. In a simulation study, we compared the MEG signals over a spherical head model with a circular hole mimicking the anterior fontanel to those over the same head model without the fontanel for different head and fontanel sizes with varying skull thickness and conductivity. The fontanel had small effects according to three indices. The sum of differences in signal over a sensor array due to a fontanel, for example, was6% of