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The introduction of HRP-labeled Tau46 capture antibodies to the FeOOH/MoBiVO4-Tau5 platform produced insoluble precipitation on the transducer by accelerating the oxidation of DAB, which amplified the photocurrent signal of FeOOH/MoBiVO4-Tau5 by 2.07-fold. Consequently, the water oxidation-coupled, FeOOH/MoBiVO4-based PEC sensing platform accurately and selectively recognized t-tau proteins down to femtomolar concentrations; the limit of detection and limit of quantification were determined to be 1.59 fM and 4.11 fM, respectively. A mini