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BACKGROUND Prunella vulgaris, commonly known as self-heal, has been extensively used in the traditional system of medicines. The plant has been found to contain a number of bioactive molecules including those having radical scavenging property which indicates its potential for the treatment of those diseases which are induced by free radical damage like drug-induced hepatotoxicity. OBJECTIVE The current study was undertaken to investigate the flavonoid and total phenolic content and evaluate the hepatoprotective potential of various ext