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The present study suggests that the observed variation in toxicity of these four metals was mainly determined by TD processes but that TK processes should not be ignored, especially for copper.A series of 3,5-bis(hetero)arylethenyl-substituted BODIPY derivatives have been prepared by Knoevenagel-type condensation of alkyl-substituted BODIPY with the corresponding aldehydes. 2-Pyrrolylethenyl-substituted derivatives feature near-IR emission (λem 700 nm) with a high fluorescence quantum yield. Both the emission maxima and fluorescenc