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Little is known about the presence and function of the tissue resident mesenchymal stem cells (MtSCs) within the gastro-intestinal mucosa in health and Inflammatory Bowel Diseases (IBD). The contribution of MtSCs to the generation of inflammatory fibroblasts during IBD is also poorly understood. We hypothesized that IBD-MtSCs are impaired and contribute to the generation of the pathological myofibroblasts in IBD. In a cohort of clinically and endoscopic active IBD patients and normal controls, we used quantitative RT-PCR and stem cell d