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The Most Effective ADHD Medication For Adults Stimulants are the first-choice treatment for adults suffering from ADHD. They help regulate levels of two chemical messages within the brain that regulate the attention. The most effective treatment for adhd for adults is Strattera (atomoxetine). It comes as an oral capsule that can be taken either with or without food. Most people find it effective. It is also more effective than more sedatives, like amp