Fleximers are different series of flexible, or “split” purine base analogues designed to learn how nucleobase flexibility affects the recognition, binding, and activity of nucleoside(tide) analogues. There is a purine base scaffold in the fleximers. With this purine base scaffold, the imidazole and pyrimidine moieties are combined by a single carbon-carbon bond, rather than being “fused” as is typical for the purines.
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