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Overexpressed ApoE restored the impaired VLDL-TAG metabolism in PNPLA7-knockdown primary hepatocytes. Conclusion PNPLA7 plays a critical role in regulating hepatic VLDL secretion by modulating ApoE stability through its interaction with ApoE. This article is protected by copyright. All rights reserved.KEY POINTS Alternaria aeroallergens induce the release of ATP from human bronchial epithelial (HBE) cells by activating a conductive pathway involving VDAC-1 and by exocytosis of ATP localized within membrane vesicles. Inhibition of VDAC