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Sex phenotype ranges from monoecy in ethylene-sensitive WT plants to androecy in the strongest ethylene-insensitive ones, via andromonoecy in the partially ethylene-insensitive plants. The induction of female flowering transition was found to be associated with an upregulation of CpACS11, CpACO2 and CpACS27, three ethylene biosynthesis genes required for female flower development. A model is proposed herewith, integrating both ethylene biosynthesis and receptor genes into the genetic network which regulates sex determination in C. pepo