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ADHD Medications - Stimulant Or Non Stimulant? Stimulant medication is the first choice for ADHD treatment, since they're the most studied and have a rapid-acting effect. But they're not right for everyone. increase signaling between nerves and brain regions to decrease ADHD symptoms. These medications can also cause negative side effects, such as a rise in heart rate or blood pressure, as well as a loss of appetite. Stimulants Stimulants are the most common medications used to treat ADHD. They are k