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This study was prepared to investigate Graviola draw out (GE) impacts on hepatic and cellular alterations caused by MSG. Fifty Wistar rats had been arbitrarily allocated into five teams control (got normal saline), Graviola (obtained 200 mg/kg weight), MSG (received 2.4 gm MSG/kg, 15% of Lethal dose (LD5 of MSG), Graviola + monosodium glutamate (MSG + GE; received GE, 200 mg/kg/day and MSG 2.4 gm/kg human body fat (BW) for the next one month), and monosodium glutamate + Graviola (obtained MS