https://www.selleckchem.com/products/PTC124.html
Rescue experiments indicated TRIM24 participation in GBM infiltrative dissemination. Chromatin immunoprecipitation, reporter gene assay, PCR, Western blot and immunohistochemistry demonstrated that TRIM24 activated the expression of pluripotency transcription factor SOX2 to regulate GBM stemness and invasion in vitro and in vivo. Finally, the close relationship between TRIM24 and SOX2 was validated by testing samples enrolled in our study and exploring external databases. Conclusions Our findings uncover essential roles of TRIM24-SOX2 ax
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