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Abnormal chloride (Cl ) transport has a detrimental impact on mucociliary clearance in both cystic fibrosis (CF) and non-CF chronic rhinosinusitis. Ginseng is a medicinal plant noted to have anti-inflammatory and antimicrobial properties. The present study aims to assess the capability of red ginseng aqueous extract (RGAE) to promote transepithelial Cl secretion in nasal epithelium. Primary murine nasal septal epithelial (MNSE) [wild-type (WT) and transgenic CFTR ], fisher-rat-thyroid (FRT) cells expressing human WT CFTR, and TMEM16A-e
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