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These outcomes define pathways operative in individual antigen-specific transformative NK cells and supply a roadmap for using this NK cell subset for particular therapeutic or prophylactic vaccine strategies.The Bruton's tyrosine kinase (BTK) inhibitor ibrutinib features powerful activity in chronic lymphocytic leukemia (CLL) but minimal curative potential on it's own. Residual signaling pathways that maintain survival of CLL cells may be targeted to enhance ibrutinib's healing activity, nevertheless the nature of the