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This systematic review will not require ethical approval, and the results will be distributed through conference and peer-reviewed publications. Our results will assist current and future research scientists on the potential use of vitamin K as a protective therapy against CVD-related complications. This protocol is registered on the International Prospective Register of Systematic Reviews (PROSPERO) registration number CRD42020151667. This protocol is registered on the International Prospective Register of Systematic Reviews (PROSPERO