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0001), with a higher proportion of responders at each time point [75% versus 71.1% (  = 0.687) at day 1, 93.2% versus 73.7% at day 3 (  = .016) and 95.5% versus 71.1% at day 7 (  = .003)], higher values of SPID (770.9 ± 23.5 vs. 507.1 ± 22.6;   .0001) and significantly greater reduction in DN4 score [-62.7 ± 25.6 vs. -39.7 ± 31.2 (   .0001)]. Both treatments were well tolerated. Orally administered TRAM/DKP 75/25 mg can be a valuable and effective option in patients with acute LBP. Orally administered TRAM/DKP 75/25 mg can be