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1% (interquartile range [IQR] 37.5%), -49.8% (IQR 29.3%), -33.5% (IQR 47.4%), and -3.6% (IQR 10.6%), respectively. In the contralateral breast, median percent changes for ctTHb, ctHHb, ctO Hb, and water fraction were + 1.8% (IQR 26.7%), -8.6% (IQR 29.3%), + 6.2% (IQR 29.5%), and + 1.9% (IQR 30.7%), respectively. We demonstrated that DOTBIS-derived measurements are modifiable with pre-surgical AKT inhibition and endocrine therapy, supporting further investigation of DOTBIS as a potential imaging assessment of response to neoadjuvant targ
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