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However, only FZR1 was validated to be overexpressed in lung tissues of COPD with LUAD and cigarette smoke extract-stimulated A549 cells, a human LUAD cell line. This study suggests overexpression of FZR1 may play a key role in the tumorigenesis of LUAD in patients with COPD. This study suggests overexpression of FZR1 may play a key role in the tumorigenesis of LUAD in patients with COPD. Endocrine therapy is the backbone therapy in estrogen receptor α (ER)-positive breast cancer, and tamoxifen resistance is a great challenge for endoc
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