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24 × 10 ) and GBM (OR  = 4.86, P = 3.23 × 10 ), but the association was primarily driven by the TERT variant rs2736100. Serum low-density lipoprotein cholesterol and plasma HbA1C showed suggestive associations with glioma (OR  = 1.11, P = 1.39 × 10 and OR  = 1.28, P = 1.73 × 10 , respectively), both associations being reliant on single genetic variants. Our study provides further insight into the aetiological basis of glioma for which published data have been mixed. Our study provides further insight into the aetiological basis of glioma