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This study highlights the utility of developing multiple GRNs within a species for detecting putative regulators of important plant pathways and providing potential targets for breeding or biotechnology applications. © 2020 American Society of Plant Biologists. All rights reserved.Ethylene plays important roles in plant growth and development. Regulation of its signaling is largely unclear especially in crops such as rice. Here, from analysis of an ethylene insensitive mutant mhz11, we identified a GDSL lipase MHZ11 which modulates ethylene signalin