Tadalafil works by inhibiting the PDE5 enzyme, which breaks down cGMP (cyclic guanosine monophosphate) in the smooth muscles of the penis. By blocking PDE5, tadalafil increases the levels of cGMP, which helps relax the muscles and dilate the blood vessels in the penis, improving blood flow. This increased blood flow helps men achieve and maintain an erection in response to sexual stimulation.
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