Progynova 2 mg is a hormone replacement therapy containing estradiol, a form of estrogen. It is primarily used to treat estrogen deficiency in peri- and postmenopausal women, relieving symptoms like hot flashes, vaginal dryness, and itching. It also helps prevent osteoporosis by maintaining bone density. Progynova is sometimes used to thicken the uterine lining in infertility treatments and must be taken under medical supervision to avoid side effects.