https://www.selleckchem.com/products/blu-945.html
Rationale Fc engineering has become the focus of antibody drug development. The current mutagenesis and in silico protein design methods are confined by the limited throughput and high cost, while the high-throughput phage display and yeast display technologies are not suitable for screening glycosylated Fc variants. Here we developed a mammalian cell display-based Fc engineering platform. Methods By using mammalian cell display and next generation sequencing, we screened millions of Fc variants for optimized affinity and specificity fo
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