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f the challenging cases of masses and classify them correctly. Also, by augmenting the dataset using different approaches and comparing with other recent YOLO based studies, it is found that augmenting the training set only is the fairest and accurate to be applied in the realistic scenarios. The proposed system showed using the experimental results the YOLO impact on the breast masses detection and classification. Especially using the anchor boxes concept in YOLO-V3 that are generated by applying k-means clustering on the dataset, we ca