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033). These finding suggest that dinaciclib as a single agent can inhibit tumor growth and improve the overall survival in KPC mice. AJTR Copyright © 2020.DNA methylation, catalyzed by DNA methyltransferases (DNMTs), is a heritable epigenetic mark, participating in numerous physiological processes. DNMT3A is of particular relevance to hematopoietic differentiation, because DNMT3A mutations are strongly related to hematopoietic malignancies. Additionally, DNMT3A deficiency has been reported to increase the hematopoietic stem cell pool by limiting their diffe