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Mechanistically, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), an integral enzyme in glycolysis pathway, may subscribe to angiogenic and neurogenic potentials of NSCs. Interestingly, the relative GAPDH mRNA expression of peripheral bloodstream mononuclear mobile was gradually diminished with aging. Meanwhile its appearance amount favorably correlated with cognitive amounts. Our results suggested that metformin presents an applicant pharmacological strategy for recruitment o
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