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Identifying hand therapists' knowledge and beliefs about pain can illuminate familiarity with modern pain science within hand therapy. The primary aim was to identify hand therapists' knowledge of pain neurophysiology. Secondary purposes were to explore demographic variation in knowledge, describe practice-related beliefs about pain science, and explore associations between knowledge and beliefs. Cross-sectional descriptive survey study. An electronic survey, including the Revised Neurophysiology of Pain Questionnaire (R-NPQ) and Likert