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To gauge the efficacy and protection of polyethylene glycol loxenatide (PEX168) monotherapy in type 2 diabetes (T2D) patients in China. The 3 groups had comparable demographics and baseline qualities. The HbA1c least-square mean (95% CI) change from baseline to week 24 had been greater for PEX168/100 μg (-1.02% [-1.21%, -0.83%]) and PEX168/200 μg (-1.34% [-1.54%, -1.15%]) than for placebo (-0.17% [-0.36%, 0.02%]); (superiority P  .0001). The proportions of patients with less tha

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rospective study. Experienced cardiologists recommend emergency coronary angiography in all resuscitated out-of-hospital cardiac arrest requiring acute revascularization and appropriately excluded one-third of patients. Rather than advocating a non-selective, or conversely, a restrictive strategy with respect to coronary angiography after out-of-hospital cardiac arrest, the findings support an individualized approach by a multidisciplinary emergency team that includes experienced cardiologists. The results should be confirmed in a larger

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Whenever investigating isotopologues, the difference in collision cross section can be assumed minimal. Because the flexibility shift of isotopologues is thus mainly caused by their difference between mass and effective temperature, the examination of isotopologues provides crucial insights into the theory of ion flexibility. However, in classical IMS run at ambient force, cluster formation with simple molecules happens, which considerably influences the transportation move

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The thermal hysteresis in the cooperative spin crossover (SCO) polymer [Fe(trz)(Htrz)2]n[BF4]n (1) has been tuned by a simple ball milling grinding process. Mechanical treatment affects the size and morphology of the crystallite domains, as confirmed by multiple complementary techniques, including ESEM, DLS, and PXRD data. Upon milling, the regular cubic shape particles recrystallize with slightly different unit cell parameters and preferential orientation. This macroscopic change significantly modifies the thermally induced SCO behavio

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Venous (VTEs) and arterial thromboembolic events (ATEs) are causes of morbidity, disability, mortality, and increase in treatment costs in cancer patients. The risk associated with immune checkpoint inhibitors (ICIs) has not yet been clarified. The primary objective of this systematic review was to evaluate the incidence of VTEs and ATEs in patients treated with ICIs as single agents or in combination with other treatments. Data from retrospective and prospective studies were selected from PubMed, EMBASE, SCOPUS, and The Cochrane Librar

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Evapotranspiration is an important aspect of the hydrological cycle in natural landscapes. In cities, evapotranspiration is typically limited by reduced vegetation and extensive impervious surfaces. Stormwater control measures (SCMs) seek, among other objectives, to move the urban hydrological cycle towards pre-development conditions, promoting processes such as infiltration and evapotranspiration. Yet, evapotranspiration is generally assumed to play a minor role in the water balance of stormwater control measures. Since established

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There is significant variability in weight loss after bariatric surgery. We hypothesize that part of this variability may be predetermined by genetic differences associated with metabolic homeostasis. MicroRNA (miRNA) are short pieces of RNA that regulate gene expression and are readily detectable in serum. They are implicated in numerous metabolic processes, including weight homeostasis. In this pilot study, we briefly review the role of miRNA, and assess the feasibility of using them in the clinical setting of obesity

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p.) also depleted hepatic GSH in TrxR1/Gsr-null livers, whereas GSH levels were not significantly affected by either treatment in wildtype livers. Curiously, however, despite depleting GSH, ascorbate treatment diminished basal DNA damage and oxidative stress markers in TrxR1/Gsr-null livers. This suggests that, although ascorbate supplementation can prevent oxidative damage, it also can deplete GSH and compromise already stressed livers.Utilization of methods involving component integration has accelerated, owing to the growth of th

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3 weeks [95% CI 16.1-28.3]) vs continued IXE Q2W treatment (median not estimable, p0.0001); 67 (85%) patients vs 30 (38%) patients relapsed, respectively. Median time to re-achieving MDA on retreatment was 4.1 weeks (95% CI 4.1-4.3); 64 (96%) of 67 patients who relapsed with treatment withdrawal re-achieved MDA on retreatment. Safety was consistent with the known safety profile for ixekizumab. Continued ixekizumab therapy is superior to ixekizumab withdrawal in maintaining low disease activity in biologic-naive patients with PsA