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Helminths like Schistosoma mansoni release excretory/secretory (E/S) products that modulate host immunity to enable infection. Extracellular vesicles (EVs) are among these E/S products, yet molecular mechanisms and functionality of S. mansoni EV interaction with host immune cells is unknown. Here we demonstrate that EVs released by S. mansoni schistosomula are internalised by human monocyte-derived dendritic cells (moDCs). Importantly, we show that this uptake was mainly mediated via DC-SIGN (CD209). Blocking DC-SIGN almost compl

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All THB1 modifications resulted in a weakening of lysine affinity and affected the coupling between Lys53 proton binding and heme redox potential. The results supported the importance of specific heme peripheral interactions for the pH stability of iron coordination and the ability of the protein to undergo redox reactions.Brevilin A (BA), is a natural biologically active ingredient derived from Centipeda minima with several reports of anti-cancer, while its anti-inflammatory activity is rarely reported. Current studies have found the d

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Potassium-ion hybrid capacitors (PIHCs) have been considered as promising potentials in mid- to large-scale storage system applications owing to their high energy and power density. However, the process involving the intercalation of K+ into the carbonaceous anode is a sluggish reaction, while the adsorption of anions onto the cathode surface is relatively faster, resulting in an inability to exploit the advantage of high energy. To achieve a high-performance PIHC, it is critical to promote the K+ insertion/desertion in anodic

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In summary, we report that CD38+ NK cells may be an unexplored therapeutic target for priming the immune system of MM patients.Analysis of observed Indian Summer Monsoon precipitation reveals more increase in extreme precipitation (in terms of its magnitude) over south India compared to north and central India during 1971-2017 (base period 1930-197. In the future, analysis of precipitation from the Coordinated Regional Downscaling Experiment indicates a southward shift of precipitation extremes over South Asia. For instance, the Arabian

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